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KMID : 0379520050210020107
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한국독성학회지
2005 Volume.21 No. 2 p.107 ~ p.113
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Apoptosis Induced by BARODON^{(R)} in Human Gastric Cancer Cells
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Jo Eun-Hye
Choi Soo-Il
Kim Soo-Rim
Cho Sung-Dae
Ahn Nam-Shik
Jung Ji-Won
Yang Se-Ran
Park Joon-Suk
Hwang Jae-Woong
Park Yong-Ho
Lee Yong-Soon
Kang Kyung-Sun
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Abstract
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[ BARODON^{(R)} ] is a multi-purpose, high functional alkali solution made by mixing and liquid-ionizing silicon, calcium, sodium, borax, organic carbon chemicals and silver. In this study, we have investigated the apoptotic potential and mechanistic insights of BARODON^{(R)} in human gastric cancer cell line (AGS cells). In MTT assay, BARODON^{(R)} reduced cell viability in AGS cells. Morphological features of apoptosis with marked cytoplasmic vacuolation and appearance of apoptotic peaks in flow cytometry were observed in AGS cells withBARODON^{(R)} treatment. In addition, BARODON^{(R)} induced apoptosis of stomach cancer cell is related to bax up-regulation, caspase 7 protease activation and subsequent cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that BARODON can induce the apoptosis of AGS cells through modulation of bcl-2 family and the activation of intrinsic caspase cascades, indicating that it is potentially useful as a anti-cancer agent.
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KEYWORD
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Gastric cancer, Apoptosis, PARP, Caspase 7
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